Viagra Australia (sildenafil) is an oral drug that is used to treat erectile dysfunction. During sexual arousal medication renews decreased erectile function by increasing blood flow to the penis.
The physiological mechanism of erection of the penis is to release nitric oxide (NO) in the cavernous body during sexual stimulation. NO activates the enzyme guanylate cyclase, which causes an increase in the level of cGMP, relaxing the smooth muscle of the corpus cavernosum and increase blood flow to them.
Viagra is a potent and selective inhibitor of cGMP-specific phosphodiesterase-5 (PDE-5) in the cavernous body, wherein PDE-5 is responsible for the breakdown of cGMP. Effects of sildenafil Austrlaia on erection are peripheral in nature. Viagra has no direct relaxing effect on isolated human corpus cavernosum but enhances the powerful relaxing effect of NO on this tissue. When the pathway to NO / cGMP is activated which happens in response to sexual stimulation, inhibition of PDE5 by sildenafil leads to increased levels of cGMP in the cavernous body. Thus, in order for sildenafil to cause a desired pharmacological effect, you need to be exposed to sexual stimulation.
Viagra is taken about 1 hour before sexual intercourse. Given the efficacy and tolerability, the dose can be increased to 100 mg or decreased to 25 mg.
The maximum recommended dose is Viagra 100 mg. The maximum recommended frequency of intake is 1 time per day. Time of onset of activity of Viagra AU may be increased when taken with food compared to the fasting state.
Most frequently reported adverse reactions such are headache, flushing, dyspepsia, visual disturbances, nasal congestion, dizziness and impaired perception of color.
Contraindications appointed by medicals for Viagra in Australia:
- Hypersensitivity to the active ingredient or any other component of the formula contained in Viagra.
- Simultaneous use of donor NO (such as amyl nitrite) or nitrates in any form is contraindicated.
- Drugs for the treatment of patients with erectile dysfunction, including sildenafil, are contraindicated for men in whom sexual activity is not recommended.